GPR119 Agonist, AS1269574 (G-Protein Coupled Receptor 119 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist), CAS [[330981-72-1]]

Produktübersicht

• Artikelname: GPR119 Agonist, AS1269574 (G-Protein Coupled Receptor 119 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist), CAS [[330981-72-1]]
• Artikelnummer: USB-217392
• Hersteller Artikelnummer: 217392
• Alternativnummer: USB-217392-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A pyrimidine compound that acts as an effective GPR119 agonist (EC50=2.5uM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward B-adrenergic or GLP-1 receptors. Shown to enhance 16.8mM glucose-induced insulin secretion from murine MIN-6 B-cells (mU/20 min=0.44 and 0.22, respectively, with or without 10uM AS1269574) in vitro and improve glucose tolerance in normal mice (100mg/kg, p.o.) without any significant hypoglycemic effect in vivo. CAS Number: 330981-72-1 Formula: C13H14BrN3O Solubility: DMSO Molecular Weight: 308.2 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 308.2
• Reinheit: ~99% (HPLC)
• Formulierung: Supplied as an amber solid.
• CAS Nummer: [330981-72-1]