PBIT (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one, 2-p-tolyl-1,2-Benzisothiazolin-3-one), CAS [[2514-30-9]]

Produktübersicht

• Artikelname: PBIT (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one, 2-p-tolyl-1,2-Benzisothiazolin-3-one), CAS [[2514-30-9]]
• Artikelnummer: USB-217429
• Hersteller Artikelnummer: 217429
• Alternativnummer: USB-217429-5,USB-217429-10,USB-217429-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It does not significantly affect the activity of UTX and JMJD3 demethylases.1 It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B Synonyms: 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one, 2-p-tolyl-1,2-Benzisothiazolin-3-one CAS No: 2514-30-9 Molecular Formula: C14H11NOS Molecular Weight: 241.31 lambdamax 259, 331 nm Purity: 98% Form: Crystalline solid Solubility: DMF: 10mg/ml. DMSO: 10mg/ml. DMSO:PBS (pH 7.2) (1:6): 0.1mg/ml. Ethanol: 1mg/ml. Storage and Stability: May be stored at -20C Stable for 6 months after receipt.

Produkteigenschaften

• Molekulargewicht: 241.31
• CAS Nummer: [2514-30-9]