Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS [[1373423-53-0]]

Produktübersicht

• Artikelname: Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS [[1373423-53-0]]
• Artikelnummer: USB-217431
• Hersteller Artikelnummer: 217431
• Alternativnummer: USB-217431-10,USB-217431-25,USB-217431-50
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable GSK-J1 prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50uM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-alpha production in primary human macrophage cultures (IC50 = 9uM by ELISA). GSK-J4 has been used to study the effect of KDM2B (Jumonji (JmjC) domain histone 3 lysine 36 (H3K36) di-demethylase) inhibition on the survival and DNA repair potential of glioblastoma cells. It has also been used in sulforhodamine B (SRB) cell growth assay and cell viability assay. Synonyms: GSK-J1 Pro-Drug, JHDM Inhibitor II Pro-Drug, Ethyl-3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoate CAS No: 1373423-53-0 Molecular Formula: C24H27N5O2 Molecular Weight: 417.5 Appearance: Tan semi-solid Purity: 98% (HPLC) CAS No: 1373423-53-0 Primary Target: H3K27me3 demethylases JMJD3 & UTX Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 417.5
• Reinheit: 98% (HPLC)
• Formulierung: Tan semi-solid
• CAS Nummer: [1373423-53-0]