HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O), CAS [[1197196-48-7]]5 m

Produktübersicht

• Artikelname: HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O), CAS [[1197196-48-7]]5 m
• Artikelnummer: USB-217435
• Hersteller Artikelnummer: 217435
• Alternativnummer: USB-217435-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A quinazolinamine compound that acts as a potent, reversible and SAM (S-adenosylmethionine) non-competitive inhibitor of methyltransferases G9a (H3K9 HMT/EHMT2, IC50=15nM, =23nM) and GLP (G9a-like protein/EHMT1, IC50=20nM). Displays 1,000-fold greater selectivity for G9a over SET7/9 (H3K4 HMTase), SET8/PreSET7 (H4K20 HMTase), PRMT3 (MTase) and JMJD2E (demethylase), and minimally affects the activities of a broad range of GPCRs, ion-channels and transporters in a 30-target selectivity panel, with the exception of muscarinic M2 receptor and histamine H1 receptors (82% and 31% inhibition at 1uM, respectively). CAS Number: 1197196-48-7 Formula: C26H43N7O2 H2O Molecular Weight: 503.7 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 503.7
• Reinheit: 97% (HPLC)
• Formulierung: Supplied as a liquid in DMSO.
• CAS Nummer: [1197196-48-7]