ILK Inhibitor, Cpd 22 (N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4-(trifluoromethyl)biphenyl-4-yl)-1H-pyrazol-3-yl)propanamide)

Produktübersicht

• Artikelname: ILK Inhibitor, Cpd 22 (N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4-(trifluoromethyl)biphenyl-4-yl)-1H-pyrazol-3-yl)propanamide)
• Artikelnummer: USB-217454
• Hersteller Artikelnummer: 217454
• Alternativnummer: USB-217454-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50=600nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50=1 to 2.5uM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model. Molecular Formula: C30H30F3N5O Molecular Weight: 553.6 Solubility: DMSO (100mg/ml) NMR: Conforms LC-MS: Conforms Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 553.6
• Reinheit: 94% (HPLC)
• Formulierung: Supplied as an off-white powder.