An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34nM, IC50 = 0.55nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA ornMDA receptors (IC50 >10uM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity. Synonyms: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone CAS Number: 409345-29-5 Molecular Formula: C20H23NO3 Molecular Weight: 325.41 Primary Target: mGlu1 Primary Target IC50: 0.55nM Primary Target Ki: 0.34nM Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
325.41
Reinheit:
98% (HPLC)
Formulierung:
Supplied as a white solid.
CAS Nummer:
[409345-29-5]
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