MIF Antagonist IV, RDR 03785 (Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol)

Produktübersicht

• Artikelname: MIF Antagonist IV, RDR 03785 (Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol)
• Artikelnummer: USB-217549
• Hersteller Artikelnummer: 217549
• Alternativnummer: USB-217549-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (Ki and IC50 = 0.57 and 2.4uM, respectively) via direct non-covalent MIF interaction ( = 24.5uM). RDR 03758 at 10uM is shown to completely neutralize the overriding effect of 100ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone in RAW 264.7 marcophage cultures. Formula: C19H18F3NO4 Molecular Weight: 381.4 Solubility: DMSO (50mg/ml, clear, colorless solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 381.4
• Reinheit: 97% (HPLC)
• Formulierung: Supplied as a cream solid.