A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria, Ki 1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Synonyms: ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) CAS No: 56396-35-1 Molecular Formula: C18H12N2O2 Molecular Weight: 288.30 Purity: 98% (HPLC) Appearance: Bright yellow solid Solubility: DMSO (100g/ml). Use fresh DMSO for reconstitution Primary Target: Mitochondria Method for Determining Identity: Proton NMR Spectroscopic and LC-MS Spectrometric Analysis Carbon: As Reported Hydrogen: As Reported Nitrogen: As Reported Water: As Reported Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at 4C. Do not freeze. Reconstitute with DMSO. Store at 4C.
Molekulargewicht:
288.3
CAS Nummer:
[56396-35-1]
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