NS8593 ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine), CAS [[875755-24-1]]
Artikelnummer:
USB-217603
Hersteller Artikelnummer:
217603
Alternativnummer:
USB-217603-10
Hersteller:
US Biological
Kategorie:
Biochemikalien
An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3, =420nM, 600nM, and 730nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50=1.6mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. Synonyms: NS8593, ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine, N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride) CAS No: 875755-24-1 Free Base: 875755-39-8 Molecular Formula: C17H17N3HCl Molecular Weight: 263.34+(36.46) Purity: 98% Appearance: White powder Solubility: DMSO (100mg/ml) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Hygroscopic. Keep tightly closed and desiccated under inert atmosphere. Light sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
263.34
CAS Nummer:
[875755-24-1]
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