PI 3,4-K Inhibitor, PIK-93 (N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide), CAS [[593960-11-3]]

Produktübersicht

• Artikelname: PI 3,4-K Inhibitor, PIK-93 (N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide), CAS [[593960-11-3]]
• Artikelnummer: USB-217657
• Hersteller Artikelnummer: 217657
• Alternativnummer: USB-217657-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50=16, 19, 39 and 64nM for p110y, PI 4-KIIb, p110a and DNA-PK, respectively). Moderately inhibits p110d, PI 3-KC2b, hsVPS34, ATM, p110b and PI 4-KIIIa (IC50=0.120, 0.140, 0.320, 0.490, 0.590 and 1.1uM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50>10uM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250nM. CAS Number: 593960-11-3 Formula: C14H16ClN3O4S2 Solubility: DMSO Molecular Weight: 389.9 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 389.9
• Reinheit: ~98% (HPLC)
• Formulierung: Supplied as a pale yellow solid.
• CAS Nummer: [593960-11-3]