PP2A Activating Ligand, ITH12246, CAS [[1228658-31-8]]

Produktübersicht

• Artikelname: PP2A Activating Ligand, ITH12246, CAS [[1228658-31-8]]
• Artikelnummer: USB-217687
• Hersteller Artikelnummer: 217687
• Alternativnummer: USB-217687-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Synonyms: PP2A Activating Ligand, ITH12246 CAS No: 1228658-31-8 Molecular Formula: C16H19N3O2HCl Molecular Weight: 285.34 Solubility: DMSO Primary Target: PP2A Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 285.34
• Reinheit: 98% (HPLC)
• Formulierung: Supplied as an off-white powder.
• CAS Nummer: [1228658-31-8]