Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. alpha1-Adrenergic blocker. Prazosin hydrochloride, a quinazole derivative, is a very potent and highly selective antagonist for apha-1-adrenoceptors (affinity for alpha-1 is about 1000-fold greater than for alpha-2 receptors). Mainly used as a clinic vasodilator for blood pressure control without increasing the heart rate or significantly impairing sympathetic functions. Has also been used clinically to treat anxiety, PTSD, and panic disorder. An excellent candidate for research studying brain functions mediated through alpha-1-adrenergic receptors, such as reward, pleasure, aggression, fear, anxiety, and addiction. CAS Number: 19237-84-4 Free Base: 19216-56-9 Molecular Formula: C19H22ClN5O4 Molecular Weight: 419.86 Appearance: White to Off-White Solid Purity: As reported Melting Point: >260C (dec.) Solubility: DMSO, Methanol, Water, Slightly soluble (<1mg/ml) in ethanol. Primary Target: 1-adrenoceptors Primary Target Ki: 0.17, 0.26, and 0.07 for 1a, 1b, and 1d adrenoceptor, respectively. Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
419.86
Reinheit:
As reported
Formulierung:
White to Off-White Solid
CAS Nummer:
[19237-84-4]
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