Rad6 Inhibitor (TZ9, HHR6 Inhibitor), CAS [[1002789-86-7]]

Produktübersicht

• Artikelname: Rad6 Inhibitor (TZ9, HHR6 Inhibitor), CAS [[1002789-86-7]]
• Artikelnummer: USB-217735
• Hersteller Artikelnummer: 217735
• Alternativnummer: USB-217735-1,USB-217735-5,USB-217735-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination. Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC50 = 6uM in 72h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction. Two known cellular Rad6 substrates, beta-catenin and PCNA, are reported to be downregulated following 24h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5uM). Synonyms: (4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, TZ9, HHR6 Inhibitor, 4-amino-6-(phenylamino)-2-(4-nitrobenzoate)-1,3,5-triazine-2-methanol CAS No: 002789-86-7 Molecular Formula: C17H14N6O4 Molecular Weight: 366.33 Purity: 98% (TLC) Appearance: Crystalline solid Primary Target: Rad6B/HHR6B Solubility: DMF, DMSO: 30mg/ml, DMSO: PBS (pH 7.2) (1:2): 0.3mg/ml Storage and Stability:. May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 366.33
• CAS Nummer: [1002789-86-7]