Rho Kinase Inhibitor XIII, RKI-1447 (1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII)

Produktübersicht

• Artikelname: Rho Kinase Inhibitor XIII, RKI-1447 (1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII)
• Artikelnummer: USB-217745
• Hersteller Artikelnummer: 217745
• Alternativnummer: USB-217745-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho Kinase inhibitor (IC50 = 14.5 and 6.2nM against ROCK1 and ROCK2, respectively), displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%, 61.9%, 56%, and 50.4% inhibition, respectively, by 1uM RKI-1447) or 15 other kinases. Selectively inhibits ROCK-dependent, but not mTORC2-dependent, cellular phosphorylations (effective conc. 0.1-1uM in MDA-MB-231, MDA-MB-468, and H1299 cultures). Shown to be efficacious in suppressing established tumor expansion in a murine ErbB2 mammary cancer model (200mg/kg/day i.p.) in vivo. Synonyms: 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate Molecular Formula: C16H14N4O2S CH3SO3H Solubility: DMSO Primary Target: Rho kinases 1 & 2 Primary Target IC50: 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively. Molar Mass: 422.5 Purity: 98% (HPLC) Form: Supplied as a yellowish white solid. Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 422.5
• Reinheit: 98% (HPLC)
• Formulierung: Supplied as a yellowish white solid.