Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1 SR 2211 selectively binds RORgamma (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORgamma activity (IC50 = 320 nM). It has minimal effects on RORalpha, LXRalpha, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 µM. Synonyms: 1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1-biphenyl]-4-yl)propan-2-ol CAS No: 1359164-11-6 Molecular Formula: C26H24F7N3O Molecular Weight: 527.5 Solubility: DMF (20mg/ml), DMSO (20mg/ml) and Ethanol (10mg/ml) lambdamax: 251 nm Purity: 98% Appearance: Crystalline solid Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
527.5
CAS Nummer:
[1359164-11-6]
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