A selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10uM. CAS Number: 199864-86-3 Formula: C17H16FN3HCl Appearance: Supplied as an off-white solid. Solubility: DMSO or EtOH Primary Target: 5-HT2B Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Reinheit:
98% (HPLC)
Formulierung:
Supplied as an off-white solid.
CAS Nummer:
[199864-86-3]
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