A cell-permeable 2-benzyloxy griseofulvin derivative that displays enhanced mammalian cancer-selective toxicity (IC50 2, 4, 12, and 30uM against panels of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively), but little antifungal activity, by activating spindle-assembly-checkpoint without affecting microtubule kinetochore attachment. Cancer cells are reported to undergo multipolar (MP) mitosis with normal or supernumerary centrosomes in the presence of GF-15, resulting in subsequent apoptotic cell death. Shown to retard HT29 colon cancer & OPM2 myeloma tumor expansion in mice (20mg/kg/day i.p.) in vivo. GF-15 half-life is expected to be least 48h in cultures. Synonyms: Supernumerary Centrosomes Clustering Inhibitor, 2-Benzyloxy-2-demethoxygriseofulvin, (2S,6R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1-(2-benzyloxy-6-methylcyclohex-2-en-4-one), (2S,5R)-3-benzyloxy-7-chloro-4,6-dimethoxy-5-methyl-spiro(benzofuran-2,4-cyclohex-2-ene)-1,3-dione, (1S,6R)-2-(benzyloxy)-7-chloro-4,6-dimethoxy-6-methyl-3H-spiro(benzofuran-2,1-cyclohex[2]ene)-3,4-dione CAS No: 888042-13-5 Molecular Formula: C23H21ClO6 Solubility: DMSO Molar Mass: 428.9 Purity: 98% (HPLC) Form: Supplied as a white solid. Storage and Stability: May be stored at 4C for 6 months after receipt.
Molekulargewicht:
428.9
Reinheit:
98% (HPLC)
Formulierung:
Supplied as a white solid.
CAS Nummer:
[888042-13-5]
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
