SC66, Akt Inhibitor XVIII ((2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone)

Produktübersicht

• Artikelname: SC66, Akt Inhibitor XVIII ((2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone)
• Artikelnummer: USB-217784
• Hersteller Artikelnummer: 217784
• Alternativnummer: USB-217784-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Molecular Formula: C18H16N2O Molecular Weight: 276.3 Solubility: DMSO (25mg/ml) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 276.3
• Reinheit: 95% (HPLC)
• Formulierung: Supplied as a pale yellow solid.