SAG Dihydrochloride, Water Soluble (Smoothened Agonist), CAS [[364590-63-6]]

Produktübersicht

• Artikelname: SAG Dihydrochloride, Water Soluble (Smoothened Agonist), CAS [[364590-63-6]]
• Artikelnummer: USB-217797
• Hersteller Artikelnummer: 217797
• Alternativnummer: USB-217797-1,USB-217797-5,USB-217797-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= 3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Synonyms: N-Methyl-N-(3-pyridinylbenzyl)-N-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 CAS No: 364590-63-6 Molecular Formula: C28H28ClN3OS 2HCl 2H2O Molecular Weight: 599 Purity: 98% (HPLC) Appearance: White to yellow solid Solubility: Water, DMSO: 10mg/ml NMR: Conforms to structure Mass Spectrophotometry: Conforms to structure Elemental Analysis: As Reported Storage and Stability: May be stored at 4C. Stable for 6 months after receipt. Reconstitute with DMSO or H2O. Aliquot and store at -20C.

Produkteigenschaften

• Molekulargewicht: 599
• CAS Nummer: [364590-63-6]