TLR3/dsRNA Complex Inhibitor (CU CPT 4a, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor), CAS [[1279713-77-7]]

Produktübersicht

• Artikelname: TLR3/dsRNA Complex Inhibitor (CU CPT 4a, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor), CAS [[1279713-77-7]]
• Artikelnummer: USB-217837
• Hersteller Artikelnummer: 217837
• Alternativnummer: USB-217837-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM, =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Synonyms: (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic Acid, CU CPT 4a CAS No: 1279713-77-7 Molecular Formula: C18H13ClFNO3S Molecular Weight: 377.8 Purity: 99% (HPLC) Appearance: White solid Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after reciept. Reconstitute with DMSO. Once dissolved, dilute in dH2O or PBS. Store at 4C. Stable for 6 months after reconstitution. Protect from light.

Produkteigenschaften

• Molekulargewicht: 377.8
• CAS Nummer: [1279713-77-7]