A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9mM). Synonyms: Vigabatrin, 4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, gamma-Vinyl-GABA, Sabril CAS No: 68506-86-5 Molecular Formula: C6H11NO2 Molecular Weight: 129.16 Solubility: H2O: 100mM Primary Target: GABA Transaminase Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
99% (HPLC)
Formulierung:
Supplied as a white solid.
CAS Nummer:
[68506-86-5]
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