WAY-100635 Maleate (5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635), CAS [[634908-75-1]]

Produktübersicht

• Artikelname: WAY-100635 Maleate (5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635), CAS [[634908-75-1]]
• Artikelnummer: USB-217874
• Hersteller Artikelnummer: 217874
• Alternativnummer: USB-217874-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro. CAS No: 634908-75-1 Molecular Formula: C25H34N4O2C4H4O4 Solubility: Water (50mM) Primary Target: 5-HT1A Water Molecules: 1mol Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at 4C. Reconstitute with sterile ddH2O. Do not freeze. Store at 4C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 538.64
• Reinheit: 97% (HPLC)
• Formulierung: Off-white solid
• CAS Nummer: [634908-75-1]