Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide)

Produktübersicht

• Artikelname: Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide)
• Artikelnummer: USB-217876
• Hersteller Artikelnummer: 217876
• Alternativnummer: USB-217876-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT, 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Formula: C14H14N4O3 Molecular Weight: 286.3 Solubility: DMSO (100mg/ml, clear, red solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 286.3
• Reinheit: 95% (HPLC)
• Formulierung: Supplied as a pinkish red solid.