| Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARy ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes. Synonyms: SQ 23377, EM 94, [2S-[2alpha[2S*,5R*(S*)],5beta(4S*,6R*,8R*,10Z,12S*,14S*,16E,18S*,19S*,20R*,21R*)]]-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2,5-dimethyl[2,2-bifuran]-5-yl]-9-oxo-10,16-docosadienoic Acid, [2S-[2alpha[2S*,5R*(S*)],5beta(4S*,6R*,8R*,10Z,12S*,14S*,16E,18S*,19S*,20R*,21R*)]]-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2,5-dimethyl[2,2-bifuran]-5-yl]-9-oxo-10,16-docosadienoic Acid, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2R,5S,5S)-octahydro-5-[(1R)-1-hydroxyethyl]-2,5-dimethyl[2,2-bifuran]-5-yl]-9-oxo-10,16-docosadienoic Acid CAS Number: 56092-81-0 Source: Streptomyces conglobatus Molecular Weight: 709.0 Molecular Formula: C41H72O9 Solubility: Methanol or DMSO. Purity: 98% (HPLC, TLC) Form: Supplied as a waxy yellow to colorless solid. Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures. |
