Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinsons-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Alternate Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide, BU 4061T CAS Number: 134381-21-8 Source: Synthetic Molecular Formula: C28H50N4O7 Molecular Weight: 554.7 Solubility: Soluble in DMSO. Insoluble in water. Purity: 97% (NMR) Appearance: Supplied as a white to off-white solid. Storage and Stability: Stable for 1 year after receipt when stored at -20C. Keep cool and dry. Protect from light and moisture. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molekulargewicht:
554.7
Reinheit:
97% (NMR)
Formulierung:
Supplied as a white to off-white solid.
CAS Nummer:
[134381-21-8]
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