Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Synonyms: 4'-Demethylepipodophyllotoxin, 9-(4,6-O-ethylidene-beta-D-glucopyranoside), (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-beta-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, EPEG, VP 16-213, VePesid, Vepesid J, Zuyeyidal, trans-Etoposide CAS No: 33419-42-0 Molecular Formula: C29H32O13 Molecular Weight: 588.56 Purity (HPLC): 95.0-105.0% Appearance: White to off-white powder Solubility: Colorless, clear solution Optical Rotation: [a]D20 = -110 to -118 Water (Karl Fischer): 6% Residue on Ignition: 0.1% Heavy Metals: 0.002% Residual Solvents: Acetone: Not detected Ethyl acetate: 0.5% Chloroform: Not Detected Related Substances: Lignan P: Not Detected Picroetoposide: Not Detected Total Impurities: 0.27% Any other individual impurity: 2% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Meets or exceeds USP specifications
Molekulargewicht:
588.56
CAS Nummer:
[33419-42-0]
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