Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin. Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10nM) in vitro. Synonyms: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin CAS Number: 75747-14-7 Molecular Weight: 585.7 Molecular Formula: C31H43N3O8 Method for Determining Identity: Mass Spectrometric Analysis Solubility: DMSO to 100mM Appearance: Supplied as a dark purple solid. Purity: 98% Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
585.7
Reinheit:
98%
Formulierung:
Supplied as a dark purple solid.
CAS Nummer:
[75747-14-7]
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