Potent and selective Iks channel blocker (IC50 values are 10.5 and 34nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo. Appearance: White solid Purity: 99% Solubility: Soluble to 10mM in DMSO, 20mM in ethanol TLC: Rf = 0.06 (30% EtOAc in petroleum spirits HPLC: 99.4% Chiral HPLC: 100%% 1H NMR: Consistent with structure Mass Spectrum: Consistent with structure Microanalysis: Carbon Hydrogen Nitrogen Theoretical 49.63 5.88 3.4 Found 49.81 5.98 3.45 Storage: Store at RT CAS No: 223749-46-0 Molecular Weight: 411.44 Formula: C17H24F3NO5S
Molekulargewicht:
411.44
Reinheit:
99%
Formulierung:
White solid
CAS Nummer:
[223749-46-0]
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