Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kdelta, PI 3-Kbeta, PI 3-Kalpha and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology- directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ). Synonyms: 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-o xo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piper azineacetamide CAS No: 881375-00-4 Molecular Formula: C33H34N4O4S Molecular Weight: 582.71 Appearance: Supplied as a beige solid. Purity: 97% Solubility: Soluble to 100mM in 2eq.HCl Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
582.71
Reinheit:
97%
Formulierung:
Supplied as a beige solid.
CAS Nummer:
[881375-00-4]
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