Selective inhibitor of TGF-beta type-I receptor (TGF-beta RI, TGFR-I, TbetaR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR-beta RI, TGF-beta RII and MLK-7K respectively). Inhibits TGF-beta-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. CAS No: 396129-53-6 Purity: 98% Solubility: Soluble to 100mM in DMSO Storage: Store at RT, Store in the dark under inert atmosphere.
Molekulargewicht:
272.3
CAS Nummer:
[396129-53-6]
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
