Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells. Synonyms: 6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine CAS No: 1262888-28-7 Molecular Formula: C15H11F2N3 Molecular Weight: 271.26 Purity: 99.9% Appearance: White to off-white powder Solubility: DMSO: 54mg/ml Ethanol : 14mg/ml. Water: Insoluble NMR: Conforms to reference Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
271.26
Reinheit:
As reported
CAS Nummer:
[1262888-28-7]
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