UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17uM respectively). Suppresses T lymphocyte mitogenesis, leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain. Synonyms: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride CAS No: 136647-02-4 Molecular Formula: C29H35NO2.HCl Molecular Weight: 466.05 Purity: 99% (HPLC) Appearance: White to off-white solid Solubility: DMSO to 50mM Ethanol to 30mM Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis TLC Conditions: Rf=0.24 (Chloroform:Methanol [25:1]) Elemental Analysis: Calculated: %C: 73.32, %H: 7.85, %N: 2.95 Storage and Stability: Long-term storage is recommended at -20C. Stable for 6 months after receipt.
Molekulargewicht:
466.05
CAS Nummer:
[136647-02-4]
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