The major toxic constituent of the mushroom, Amanita phalloides. Inhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin. Synonyms: alpha-Amatoxin, cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic (48)-sulfide (R)-S-oxide CAS No: 23109-05-9 Molecular Formula: C39H54N10O14S Molecular Weight: 918.97 Appearance: White to off-white solid Purity: 98% Melting Point: 254-255C (lit.) Solubility: Soluble to 5mM in ethanol and to 5mM in water Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20C and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Molekulargewicht:
918.97
Reinheit:
90%
CAS Nummer:
[23109-05-9]
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
