Z-L-Alanine is a cytosolic enzyme inhibitor that inhibits the activity of enzymes involved in protein catalysis. This inhibition is stereoselective, with the L-enantiomer having the stronger inhibitory effect. Z-L-Alanine has been shown to be an effective inhibitor of proteolytic enzymes and has been used as an additive in buffers to prevent enzymatic degradation. Molecular modeling studies have demonstrated that Z-L-Alanine can bind to the active site of these enzymes and inhibit their activity by binding to the catalytic triad of serine, aspartate, and histidine residues. The molecular structure of Z-L-Alanine resembles that of a natural substrate for these enzymes, which may account for its effectiveness in inhibiting them. FTIR spectroscopy has confirmed the presence of Z-L-alanine in a sample obtained from a bacterial culture. Synonyms: Z-L-Ala-OH, (S)-2-(Benzyloxycarbonylamino)propanoic Acid, (S)-2-[(Benzyloxycarbonyl)amino]propionic Acid, Benzyloxycarbonyl-L-alanine, L-Carbobenzoxyalanine, L-Carbobenzyloxyalanine, L-N-(Benzyloxycarbonyl)alanine, N-(Benzyloxycarbonyl)-(S)-alanine, N-(Carbobenzoxy)-L-alanine, N-Benzoxycarbonyl-L-alanine, N-Carbobenzyloxy-L-alanine, N-[(Benzyloxy)carbonyl]-L-alanine, N-[(Phenylmethoxy)carbonyl]-L-alanine, NSC 156978, NSC 88469 CAS No: 1142-20-7 Molecular Formula: C11H13NO4 Molecular Weight: 223.20 Appearance: White to off-white crystalline powder Purity: 99.5% (Chiral HPLC) Melting Point: 80-90C Optical Rotation: [a]20D = -12 3 (C=1 in AcOH) Solubility: Chloroform (Slightly), Methanol (Slightly) Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
223.2
Reinheit:
99.5% (Chiral HPLC)
Formulierung:
White to off-white crystalline powder
CAS Nummer:
[1142-20-7]
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