Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform. Acetylcholine chloride, injected at 20mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with alpha7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6. Synonyms: 2-(Acetyloxy)-N,N,N-trimethylethanaminium chloride, 2-Acetoxyethyltrimethylammonium chloride, N-(2-Hydroxyethyl)trimethylammonium chloride acetate, Acecoline, Arterocoline, Miochol, Ovisot CAS No: 60-31-1 Molecular Formula: C7H16ClNO2 Molecular Weight: 181.66 Purity (Titration): 99% Appearance: White to off-white solid Melting Point: As reported Loss on Drying: 1% Solubility: Chloroform (Slightly), Methanol (Slightly) Storage and Stability: Store at RT under inert atmosphere. Very Hygroscopic.
Molekulargewicht:
181.66
Reinheit:
99% (Titration)
Formulierung:
White to off-white solid
CAS Nummer:
[60-31-1]
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