BOP, also known with the name of Castros reagent, is a phosphonium coupling reagent used for peptide synthesis. BOP can be employed in presence of a base such as triethylamine or Hünigs base and forms HOBt in situ, which then generates an activated ester. BOP is a very effective coupling reagent, achieving high yields, low epimerisation and high conversion rates. However, it forms the extremely toxic and carcinogenic HMPA in situ, therefore the equally efficient pyrrolidino derivative PyBOP was introduced, which leads to a less toxic by-product. Synonyms: Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate, Castro's Reagent, BOP CAS No: 56602-33-6 Molecular Formula: C12H22F6N6OP2 Molecular Weight: 442.28 Appearance: White to yellow-beige powder Purity: 98% Melting Point: 138-145C Solubility: DMF Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
442.28
Reinheit:
98%
Formulierung:
White to yellow-beige powder
CAS Nummer:
[56602-33-6]
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