Clavulanic acid is a beta-lactamase inhibitor that prevents the destruction of penicillin and other beta-lactam antibiotics by bacterial enzymes. It has been shown to have inhibitory levels against a wide range of bacteria, including those that are resistant to amoxicillin, such as Streptococcus pneumoniae, Haemophilus influenzae, Proteus mirabilis, and Enterobacter cloacae. Clavulanic acid also inhibits the production of toxins in bacterial rhinosinusitis. The mechanism of action for clavulanic acid is inhibition of bacterial topoisomerases I and II, which are involved in replication and transcription. This drug also binds to potassium ions and forms clavulanate ion, which can be hydrolyzed by esterases or glucuronidases. Synonyms: (2R,5R,Z)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid CAS No: 58001-44-8 Molecular Formula: C8H9NO5 Molecular Weight: 199.16 Appearance: White to off-white powder Purity: 98% Solubility: DMSO: 13.89mg/ml (69.74mM, ultrasonic and warming and heat to 60C), Water 40mg/ml (ultrasonic) Storage and Stability: Store at 4C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
199.16
Reinheit:
98%
Formulierung:
White to off-white powder
CAS Nummer:
[58001-44-8]
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