The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic, abortifacient. Inhibits NLRP3 by acting through receptor EP4 activation that increases cAMP and phosphorylates NLRP3 at serine 295 through PKA. PKA phosphorylation of NLRP3 inhibits the NLRP3 ATPase activity, which is required for assembly of NLRP3-ASC complexes. A metabolite of arachidonic acid, synthesised by COX enzymes and prostaglandin E synthases (PGEs). Binds to EP1, EP2, EP3 and EP4 receptors with high affinity (Kd < 10 nM). Therapeutic potential for analgesia, pain relief and arthritic diseases. Enhances differentiation and expansion of iPSC-derived hematopoietic progenitor cells Synonyms: (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid, 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid, (-)-Prostaglandin E2, (15S)-Prostaglandin E2, Cervidil, Cerviprime, Cerviprost, Dinoprostone, Minprostin E2, PGE2, Prepidil CAS No: 363-24-6 Molecular Formula: C20H32O5 Molecular Weight: 352.47 Purity: 98% (HPLC) Appearance: White to off-white crystalline powder Melting Point: 66-68C (lit) Storage and Stability: Store at -20C. Stable for 6 months after receipt.
Molekulargewicht:
352.47
Reinheit:
98% (HPLC)
Formulierung:
White to off-white crystalline powder
CAS Nummer:
[363-24-6]
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