| Hydroxocobalamin is a vitamin that has a specific antidote for cyanide poisoning. Hydroxocobalamin is synthesized from hydroxycobalamin, which is produced by the reaction of cyanide with cytochrome c in the presence of ferric ion, and it can be administered orally or intravenously. Hydroxocobalamin reacts with cyanide to form cyanocobalamin and releases the toxic hydrogen cyanide gas as a by-product. Hydroxocobalamin also has effects on cardiac tissue as it increases mitochondrial cytochrome C oxidase activity. The thermodynamic data for hydroxocobalamin are not available because this compound is unstable in water. Synonyms: Alpha Cobione, AlphaRedisol, Axlon, Ciplamin H, Hydroxo-cobalamin, Cobalex, Cobalin H, Cobinamide hydroxide phosphate 3-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole Inner Salt, Codroxomin, Docclan, Docelan, Docevita, Droxomin, Ducobee Hy, Duradoce, Duralta-12, Hydrocobalamin, Hydrogrisevit, Hydrovit, Hydroxocobalamin, Hydroxocobalamine, Hydroxocobemine, Hydroxy vitamin B12, Hydroxycobalamin, Hydroxycobalamine, Hyxobamine, Idrogrisevit, Megamilbedoce, Neo-Betalin 12, Neo-Cytamen, Neo-Macrabin, Neo-Rojamin, OH-Duphar, Oxobemin, Primabalt RP, Redisol H, Sytobex H, Vibeden, Vitadurin, Vitamin B12a, alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide CAS No: 13422-51-0 Molecular Formula: C62H89CoN13O15P Molecular Weight: 1346.36 Appearance: Dark red to very dark purple solid Purity: 95% Identification (A) FTIR: Conforms to reference Identification (B): Positive for Cobalt Identification (C) Retention Time: Conforms to reference pH: 8-10 Water: 14-18% RELATED COMPOUNDS: B6-Hydroxymethyl Derivative: 0.50% B5-Hydroxymethyl Derivative: 0.40% Impurity, Relative Retention Time, 0.70: 0.30% Impurity, Relative Retention Time, 0.75 0.4% Impurity, Relative Retention Time, 0.82 0.40% Impurity, Relative Retention Time, 0.93 1.1% C8 Epimer: 1.0% Impurity, Relative Retention Time, 1.37-1.51: 0.50% Cyanoobalamin: 1% Other Impurity: 0.20% Sum of all Impurities: 4% Acetone: 0.5% Arsenic (As): As reported Residual Solvents: As reported Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly) Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
