5a-Pregnane-3a,20a-diol is a gamma-aminobutyric acid (GABA) analogue that is used in the treatment of women with variegated hyperpigmentation. It has inhibitory properties on mutant enzymes such as disulfate reductase and other enzymes involved in the synthesis of prostaglandins. The drug binds to the enzyme GABA transaminase and this binding prevents the formation of GABA from glutamate. 5a-Pregnane-3a,20a-diol also inhibits the synthesis of prostaglandin E2 by binding to cyclooxygenase 2, leading to decreased inflammation and pain. 5a-Pregnane-3a,20a-diol is metabolized by glucuronidation or sulfation and excreted into bile or urine. This drug can also be hydrolyzed by dehydrogenases or other enzymes such as esterases. Synonyms: xxx CAS No: 566-58-5 Molecular Formula: xxx Molecular Weight: xxx Appearance: White to off-white powder Purity: 98% 1H NMR: Conforms to reference Melting Point: xxxC Solubility: xxx Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Reinheit:
98%
Formulierung:
White to off-white powder
CAS Nummer:
[566-58-5]
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