Inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide, 4-[4-[N-(4-Chloro-3-trifluoromethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid Methylamide, BAY 73-4506, Fluoro-Sorafenib, Stivarga CAS Number: 755037-03-7 Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482.82 Appearance: Supplied as a white to off-white powder. Purity: 99% (HPLC, TLC) Melting Point: 185-186C Solubility: DMSO Elemental Analysis: Calculated: %C: 52.24 %H: 3.13 %Cl: 7.34 %F: 15.74 %N: 11.60 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
482.82
Reinheit:
99% (HPLC, TLC)
Formulierung:
Supplied as a white to off-white powder.
CAS Nummer:
[755037-03-7]
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