A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells. Synonyms: Ademetionine Disulfate Tosylate, 4-Methylbenzenesulfonate (salt) Sulfate (salt) (1:1:1:1) (9CI), FO 1561, S-Adenosyl-L-methionine Disulfate Tosylate, 5-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5-deoxyadenosine Sulfate 4-Methylbenzenesulfonate Sulfate, (3S)-5-[(3-Amino-3-carboxypropyl)methylsulfonio]-5-deoxyadenosine Sulfate 4-Methylbenzenesulfonate, 5-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5-deoxyadenosine Sulfate 4-methylbenzenesulfonate Sulfate CAS No: 97540-22-2 Free Base: 28594-13-0 Molecular Formula: C22H34N6O16S4 Molecular Weight: 766.8 Appearance: White to off-white crystalline powder Purity: 95% Melting Point: >122C (dec.) (lit) Heavy Metals: 0.001% Water (Karl Fischer): 2% Storage and Stability: Store at 4C. Stable for 6 months after receipt.
Molekulargewicht:
766.8
Reinheit:
95%
Formulierung:
White to off-white crystalline powder
CAS Nummer:
[97540-22-2]
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