S-(5'-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-beta-synthase (CBS). S-(5'-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles. Synonyms: 5-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5-deoxyadenosine dihydrochloride, 5-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5-deoxyadenosine dihydrochloride, S-Adenosylmethionine dihydrochloride, SAM chloride dihydrochloride, Active Methionine Disulfate, Ademetionine dihydrochloride, L-S-Adenosylmethionin dihydrochloride, S-Adenosyl-L-methionine dihydrochloride CAS No: 86867-01-8 Dichloride salt: 24346-00-7 Molecular Formula: C15H23ClN6O5S2HCl Molecular Weight: 507.82 Purity: 75% Appearance: White to off-white powder Solubility: Colorless to light yellow, clear to slightly hazy Water (KF): 8% Storage and Stability: Store at -20C. Stable for 6 months after receipt. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molekulargewicht:
507.82
Reinheit:
75%
Formulierung:
White to off-white powder
CAS Nummer:
[86867-01-8]
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