| An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG). Synonyms: Guanosine 3,5-Phosphate (cyclic), 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin Guanosine Deriv., 3,5-Cyclic GMP, 3,5-GMP, Cyclic 3,5-GMP, Cyclic 3,5-Guanylic Acid, Cyclic GMP, Cyclic Guanosine 3,5-Monophosphate, Cyclic Guanosine Monophosphate, Guanosine 3,5-Monophosphate, Guanosine 3,5-Phosphate, Guanosine Cyclic 3,5-Monophosphate, Guanosine Cyclic 3,5-Phosphate, cGMP, Guanosine Cyclic 3,5-(Hydrogen Phosphate) CAS No: xxx Molecular Formula: C10H12N5O7P Molecular Weight: 345.21 Appearance: White to off-white solid Purity: 96% Melting Point: >242C (dec.) Solubility: Water Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
