Ganglioside GM1, Bovine, Sodium Salt (Monosialoganglioside GM1), CAS [[37758-47-7]]

Produktübersicht

• Artikelname: Ganglioside GM1, Bovine, Sodium Salt (Monosialoganglioside GM1), CAS [[37758-47-7]]
• Artikelnummer: USB-297010
• Hersteller Artikelnummer: 297010
• Alternativnummer: USB-297010-25
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gan- gliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kB and activation of dendritic cells. GM1 has also been shown to improve Parkinsons disease symptoms and slow its progression Synonyms: Monosialoanglioside GM1, sodium salt (Bovine brain CAS No: 37758-47-7 Molecular Formula: C73H131N3O31 Molecular Weight: 1546.82 (Free acid basis) Purity: 95% (HPLC) 95% (Typically 99%) Appearance: White to off-white powder FT-IR Spectrum: Conforms to structure Storage and Stability: Powder may be stored at -20C. Stable for 6 months after receipt.

Produkteigenschaften

• Molekulargewicht: 1546.82
• Reinheit: 95% (Typically 99%)
• CAS Nummer: [37758-47-7]