GM2-oligosaccharide (sodium salt) is a trisaccharide (GalNAci1,4Gali1,4Glc) with sialic acid linked i2,3 to the central galactose residue (Ledeen, 2009). The parent GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumors of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of GM2 ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus (Zhu, 2018). Synonyms: GalNAci1,4Gali1,4Glc Molecular Formula: C31H51N2O24Na Molecular Weight: 858.73 Appearance: White to brown powder Purity: 85% Identity (1H NMR): Conforms to reference Solubility: As reported Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
858.73
Reinheit:
85%
Formulierung:
White to brown powder
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