Natriuretic Peptide Receptor A, Human, aa294-308 (NPR-A)

Produktübersicht

• Artikelname: Natriuretic Peptide Receptor A, Human, aa294-308 (NPR-A)
• Artikelnummer: USB-298208
• Hersteller Artikelnummer: 298208
• Alternativnummer: USB-298208-100,USB-298208-1
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides, they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2, MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] Source: Synthetic human NPR-A AA Sequence: LKQLKHLAYEQFNFT Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: ~95% (HPLC)
• Formulierung: Supplied as a lyophilized powder. Reconstitute with 0.1% acetic acid.