CD137L, Recombinant, Human, aa50-254, His-Tag (4-1BB Ligand, 4-1BBL, Tumor Necrosis Factor Ligand Superfamily Member 9, TNFSF9)
Artikelnummer:
USB-298389
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| Artikelname: | CD137L, Recombinant, Human, aa50-254, His-Tag (4-1BB Ligand, 4-1BBL, Tumor Necrosis Factor Ligand Superfamily Member 9, TNFSF9) |
| Artikelnummer: | USB-298389 |
| Hersteller Artikelnummer: | 298389 |
| Alternativnummer: | USB-298389-100 |
| Hersteller: | US Biological |
| Kategorie: | Molekularbiologie |
| The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]. Source: Recombinant protein corresponding to aa50-254 from human CD137L, fused to His-tag at N-terminal, expressed in HEK293 cell expression system. Molecular Weight: ~24kD Endotoxin: <1EU/ug Applications: Suitable for use in studying protein binding and for screening small molecules and antibodies. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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