ProSAAS is a newly discovered protein with a neuroendocrine distribution generally similar to that of prohormone convertase 1 (PC1), a peptide processing endopeptidase. ProSAAS mRNA is broadly distributed among neurons in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas). Overexpression of ProSAAS in the AtT-20 cells substantially reduces the rate of processing of POMC(endogenous prohormone proopiomelanocortin) [1]. In wild type mouse brain and pituitary, the majority of ProSAAS is processed into smaller peptides including Little SAAS, PEN and big LEN.[2] A few obesity related propeptides have been processed by PC1 and obesity has been observed to be associated with mutations in the human PC1 gene[3].Does proSAAS- derived peptides play a role in the development of obesity? Source: aa221-240, Rat Molecular Weight: ~2045.08 Sequence: Ala-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu-Leu Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
2045.08
Reinheit:
~95% (HPLC)
Formulierung:
Supplied as a white powder.
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