| May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882}. Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10ng/ml. Sequence: ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD Molecular Weight: 14.6kD PubMed ID: 2719964, 2910856, 2719646, 18824694, 1988031, 12761501, 15461802, 14702039, 10591208, 15489334, 3065332, 12665801, 3611046, 1386213, 2383549, 7501023, 10e369126, 10764829, 11146440, 14617626, 19497882, 19608861, 21269460, 22905912, 22223895, 22814378, 23131994, 24275569, 260910e39, 15476813, 18796645, 19128029 Gene Name: LGALS1 Swiss Prot: P09382 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
